a-Amino N-butyric Acid Stimulates Fetal Hemoglobin in the Adult
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چکیده
The effect of a-amino-N-butyric acid (aABA) on fetal hemoglobin production in the adult was examined in vivo after being administered to normal and anemic baboons and in erythroid progenitor cell cultures. Infusion of aABA for five days resulted in fourto fivefold increases in the level of F reticulocytes of normal or chronically anemic baboons. The induction of HbF by aABA was strikingly enhanced by the administration of 5-azacytidine. The addition of aABA in culture produced a concentration-related increase of HbF in baboon CFUe and e-cluster colonies. In addition to the induction of HbF. aABA stimulated the
منابع مشابه
alpha-Amino-N-butyric acid stimulates fetal hemoglobin in the adult.
The effect of alpha-amino-N-butyric acid (alpha ABA) on fetal hemoglobin production in the adult was examined in vivo after being administered to normal and anemic baboons and in erythroid progenitor cell cultures. Infusion of alpha ABA for five days resulted in four- to fivefold increases in the level of F reticulocytes of normal or chronically anemic baboons. The induction of HbF by alpha ABA...
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